5-HT(1B)-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan

AIMS: 5-HT(1B)-receptor mediated vasoconstriction of cranial arteries is a potential mechanism by which 5-HT(1B/1D)-receptor agonists such as sumatriptan produce their antimigraine effects. 5-HT(1B)-receptors exist in other blood vessels which may give rise to unwanted vascular effects. Therefore we...

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Hlavní autoři: Razzaque, Z, Pickard, J D, Ma, Q-P, Shaw, D, Morrison, K, Wang, T, Longmore, J
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2002
Témata:
Pharmacodynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874302/
https://ncbi.nlm.nih.gov/pubmed/11874390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01536.x
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