Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

Ecteinascidin 743 (ET-743), a highly promising marine-based antitumor agent presently in phase II clinical trials, has been shown to interfere with the binding of minor-groove-interacting transcription factors, particularly NF-Y, with their cognate promoter elements in vitro. We have shown that NF-Y...

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Bibliografske podrobnosti
Main Authors: Jin, Shengkan, Gorfajn, Barbara, Faircloth, Glynn, Scotto, Kathleen W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18735/
https://ncbi.nlm.nih.gov/pubmed/10841572
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