The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

Huntington's Disease (HD) is caused by an expansion of a polyglutamine tract within the huntingtin (htt) protein. Pathogenesis in HD appears to include the cytoplasmic cleavage of htt and release of an amino-terminal fragment capable of nuclear localization. We have investigated potential conse...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Steffan, Joan S., Kazantsev, Aleksey, Spasic-Boskovic, Olivera, Greenwald, Marilee, Zhu, Ya-Zhen, Gohler, Heike, Wanker, Erich E., Bates, Gillian P., Housman, David E., Thompson, Leslie M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2000
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC18731/
https://ncbi.nlm.nih.gov/pubmed/10823891
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares