Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1

Disruptions of LGI1 in glioblastoma (GBM) cell lines and LGI1 mutations in families with autosomal dominant epilepsy imply a role for LGI1 in glial cells as well as in neurons. Although we and others could not find LGI1 mutations in malignant gliomas, our initial studies appeared to support the idea...

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Detalhes bibliográficos
Main Authors: Piepoli, Tiziana, Jakupoglu, Cemile, Gu, Wenli, Lualdi, Elena, Suarez-Merino, Blanca, Poliani, Pietro L., Cattaneo, Maria Grazia, Ortino, Barbara, Goplen, Dorota, Wang, Jian, Mola, Rosa, Inverardi, Francesca, Frassoni, Carolina, Bjerkvig, Rolf, Steinlein, Ortrud, Vicentini, Lucia M., Brüstle, Oliver, Finocchiaro, Gaetano
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2006
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871933/
https://ncbi.nlm.nih.gov/pubmed/16533756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2005-006
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