Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1

Disruptions of LGI1 in glioblastoma (GBM) cell lines and LGI1 mutations in families with autosomal dominant epilepsy imply a role for LGI1 in glial cells as well as in neurons. Although we and others could not find LGI1 mutations in malignant gliomas, our initial studies appeared to support the idea...

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Bibliografiska uppgifter
Huvudupphovsmän: Piepoli, Tiziana, Jakupoglu, Cemile, Gu, Wenli, Lualdi, Elena, Suarez-Merino, Blanca, Poliani, Pietro L., Cattaneo, Maria Grazia, Ortino, Barbara, Goplen, Dorota, Wang, Jian, Mola, Rosa, Inverardi, Francesca, Frassoni, Carolina, Bjerkvig, Rolf, Steinlein, Ortrud, Vicentini, Lucia M., Brüstle, Oliver, Finocchiaro, Gaetano
Materialtyp: Artigo
Språk:Inglês
Publicerad: Duke University Press 2006
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871933/
https://ncbi.nlm.nih.gov/pubmed/16533756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2005-006
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