Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma,

Penicillamine is an oral agent used to treat intracerebral copper overload in Wilson’s disease. Copper is a known regulator of angiogenesis; copper reduction inhibits experimental glioma growth and invasiveness. This study examined the feasibility, safety, and efficacy of creating a copper deficienc...

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Библиографические подробности
Главные авторы: Brem, Steven, Grossman, Stuart A., Carson, Kathryn A., New, Pamela, Phuphanich, Surasak, Alavi, Jane B., Mikkelsen, Tom, Fisher, Joy D.
Формат: Artigo
Язык:Inglês
Опубликовано: Duke University Press 2005
Предметы:
Clinical Investigations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871917/
https://ncbi.nlm.nih.gov/pubmed/16053699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/S1152851704000869
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