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Human erythropoietin dimers with markedly enhanced in vivo activity

Human erythropoietin, a widely used and important therapeutic glycoprotein, has a relatively short plasma half-life due to clearance by glomerular filtration as well as by other mechanisms. We hypothesized that an erythropoietin species with a larger molecular size would exhibit an increased plasma...

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Bibliographic Details
Main Authors: Sytkowski, Arthur J., Lunn, Elizabeth Dotimas, Davis, Kerry Lynn, Feldman, Laurie, Siekman, Suvia
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC18713/
https://ncbi.nlm.nih.gov/pubmed/9448306
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