Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

Certain types of human papillomaviruses (HPVs) are closely linked to the development of human cancers. Herein, it is shown that intracellular targeting of the HPV16 E6 oncoprotein by E6-binding peptide aptamers resulted in the apoptotic elimination of HPV16-positive cancer cells, whereas HPV-negativ...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Butz, Karin, Denk, Claudia, Ullmann, Angela, Scheffner, Martin, Hoppe-Seyler, Felix
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18705/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110538897
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