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Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

Certain types of human papillomaviruses (HPVs) are closely linked to the development of human cancers. Herein, it is shown that intracellular targeting of the HPV16 E6 oncoprotein by E6-binding peptide aptamers resulted in the apoptotic elimination of HPV16-positive cancer cells, whereas HPV-negativ...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Butz, Karin, Denk, Claudia, Ullmann, Angela, Scheffner, Martin, Hoppe-Seyler, Felix
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18705/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829072/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110538897
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