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Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent

The mutational response of mismatch repair-deficient animals to the alkylating agent N-methyl-N-nitrosourea was evaluated by using a transgenic lacI reporter system. Although the mutations detected in MSH2 heterozygotes were similar to those of controls, MSH2(−/−) animals demonstrated striking incre...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Andrew, Susan E., McKinnon, Margaret, Cheng, Benjamin S., Francis, Agnes, Penney, Janice, Reitmair, Armin H., Mak, Tak W., Jirik, Frank R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18694/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448296/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1126
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