Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent
The mutational response of mismatch repair-deficient animals to the alkylating agent N-methyl-N-nitrosourea was evaluated by using a transgenic lacI reporter system. Although the mutations detected in MSH2 heterozygotes were similar to those of controls, MSH2(−/−) animals demonstrated striking incre...
Gespeichert in:
| Veröffentlicht in: | Proc Natl Acad Sci U S A |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1998
|
| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18694/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1126 |
| Tags: |
Keine Tags, Fügen Sie das erste Tag hinzu!
|