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Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of α/γ Conformers

We present here the parmbsc0 force field, a refinement of the AMBER parm99 force field, where emphasis has been made on the correct representation of the α/γ concerted rotation in nucleic acids (NAs). The modified force field corrects overpopulations of the α/γ = (g+,t) backbone that were seen in lo...

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Detalhes bibliográficos
Main Authors: Pérez, Alberto, Marchán, Iván, Svozil, Daniel, Sponer, Jiri, Cheatham, Thomas E., Laughton, Charles A., Orozco, Modesto
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868997/
https://ncbi.nlm.nih.gov/pubmed/17351000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.097782
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