Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

The anti-apoptotic proteins Bcl-2 and Bcl-X(L) bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues 114–123). The physical interaction between Beclin-1 and Bcl-X(L) is lost when the BH3 domain of Bec...

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Autori principali: Maiuri, M Chiara, Le Toumelin, Gaëtane, Criollo, Alfredo, Rain, Jean-Christophe, Gautier, Fabien, Juin, Philippe, Tasdemir, Ezgi, Pierron, Gérard, Troulinaki, Kostoula, Tavernarakis, Nektarios, Hickman, John A, Geneste, Olivier, Kroemer, Guido
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868901/
https://ncbi.nlm.nih.gov/pubmed/17446862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601689
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