The loss of immunodominant epitopes affects interferon-γ production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro

In the present study, we examined the effect of the loss of the human leucocyte antigen (HLA)-B*3501-restricted nucleoprotein (NP)(418−426) epitope on interferon (IFN)-γ-production and lytic activity of the human cytotoxic T lymphocyte (CTL) response in vitro. Extensive amino acid variation at T cel...

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Hlavní autoři: Berkhoff, E G M, Geelhoed-Mieras, M M, Verschuren, E J, van Baalen, C A, Gruters, R A, Fouchier, R A M, Osterhaus, A D M E, Rimmelzwaan, G F
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2007
Témata:
Basic Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868867/
https://ncbi.nlm.nih.gov/pubmed/17326762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2007.03340.x
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