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Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis

BACKGROUND: Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and expression of VEGFR2 is reduced in motor neuron...

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Detalhes bibliográficos
Main Authors: Brockington, Alice, Wokke, Beatrijs, Nixon, Hannah, Hartley, Judith, Shaw, Pamela J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868706/
https://ncbi.nlm.nih.gov/pubmed/17456229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-8-23
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