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Overexpression of bax Associated with Mutations in the Loop-Sheet-Helix Motif of p53

Recent investigations have revealed that mutations of the loop-sheet-helix motif of p53 is a significant factor for a poor prognosis in patients with non-small-cell lung cancer (NSCLC). To clarify this mechanism, bcl-2 and bax expression were evaluated in relation to mutations of p53. Tumor tissues...

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Autors principals: Huang, Cheng-long, Kohno, Nobuoki, Inufusa, Haruhiko, Kodama, Ken, Taki, Toshihiko, Miyake, Masayuki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868607/
https://ncbi.nlm.nih.gov/pubmed/10487853
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