Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses

BACKGROUND: The Sleeping Beauty (SB) transposon system is a non-viral vector system that can integrate precise sequences into chromosomes. We evaluated the SB transposon system as a tool for gene therapy of mucopolysaccharidosis (MPS) types I and VII. METHODS: We constructed SB transposon plasmids f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Aronovich, Elena L., Bell, Jason B., Belur, Lalitha R., Gunther, Roland, Koniar, Brenda, Erickson, David C. C., Schachern, Patricia A., Matise, Ilze, McIvor, R. Scott, Whitley, Chester B., Hackett, Perry B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868578/
https://ncbi.nlm.nih.gov/pubmed/17407189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1028
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg