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Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer’s Disease
In Alzheimer’s disease (AD) brain the activity of protein phosphatase (PP)-2A is compromised and that of the extracellular signal-regulated protein kinase (ERK1/2) of the mitogen-activated protein kinase (MAPK) family, which can phosphorylate tau, is up-regulated. We investigated whether a decrease...
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Autori principali: | , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
American Society for Investigative Pathology
2003
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868262/ https://ncbi.nlm.nih.gov/pubmed/12937126 |
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