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Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer’s Disease

In Alzheimer’s disease (AD) brain the activity of protein phosphatase (PP)-2A is compromised and that of the extracellular signal-regulated protein kinase (ERK1/2) of the mitogen-activated protein kinase (MAPK) family, which can phosphorylate tau, is up-regulated. We investigated whether a decrease...

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Autori principali: Pei, Jin-Jing, Gong, Cheng-Xin, An, Wen-Lin, Winblad, Bengt, Cowburn, Richard F., Grundke-Iqbal, Inge, Iqbal, Khalid
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868262/
https://ncbi.nlm.nih.gov/pubmed/12937126
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