Induction of Fatal Inflammation in LDL Receptor and ApoA-I Double-Knockout Mice Fed Dietary Fat and Cholesterol

Atherogenic response to dietary fat and cholesterol challenge was evaluated in mice lacking both the LDL receptor (LDLr(−/−)) and apoA-I (apoA-I(−/−)) gene, LDLr(−/−)/apoA-I(−/−) or double-knockout mice. Gender- and age-matched LDLr(−/−)/apoA-I(−/−) mice were fed a diet consisting of 0.1% cholestero...

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Main Authors: Zabalawi, Manal, Bhat, Shaila, Loughlin, Tara, Thomas, Michael J., Alexander, Eric, Cline, Mark, Bullock, Bill, Willingham, Mark, Sorci-Thomas, Mary G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2003
Fag:
Animal Model
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868257/
https://ncbi.nlm.nih.gov/pubmed/12937162
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