Dysfunctional HDL Containing L159R ApoA-I Leads to Exacerbation of Atherosclerosis in Hyperlipidemic Mice

The mutation L159R apoA-I or apoA-I(L159R) (FIN) is a single amino acid substitution within the sixth helical repeat of apoA-I. It is associated with a dominant negative phenotype, displaying hypoalphaproteinemia and an increased risk for atherosclerosis in humans. Mice lacking both mouse apoA-I and...

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Detalhes bibliográficos
Main Authors: Sorci-Thomas, Mary G., Zabalawi, Manal, Bharadwaj, Manish S., Wilhelm, Ashley J., Owen, John S., Asztalos, Bela F., Bhat, Shaila, Thomas, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690280/
https://ncbi.nlm.nih.gov/pubmed/21944998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2011.08.019
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