AP-1 Mediated Relief of Repressive Activity of the CD30 Promoter Microsatellite in Hodgkin and Reed-Sternberg Cells

Overexpression of CD30 is the hallmark of Hodgkin and Reed-Sternberg (H-RS) cells and drives constitutive nuclear factor-κB activation that is the molecular basis for the pathophysiology of Hodgkin’s lymphoma. Transcription of the CD30 gene is controlled by the core promoter that is driven by Sp-1 a...

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Библиографические подробности
Главные авторы: Watanabe, Mariko, Ogawa, Yuji, Ito, Kinji, Higashihara, Masaaki, Kadin, Marshall E., Abraham, Lawrence J., Watanabe, Toshiki, Horie, Ryouichi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2003
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Regular Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868231/
https://ncbi.nlm.nih.gov/pubmed/12875982
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