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AP-1 Mediated Relief of Repressive Activity of the CD30 Promoter Microsatellite in Hodgkin and Reed-Sternberg Cells
Overexpression of CD30 is the hallmark of Hodgkin and Reed-Sternberg (H-RS) cells and drives constitutive nuclear factor-κB activation that is the molecular basis for the pathophysiology of Hodgkin’s lymphoma. Transcription of the CD30 gene is controlled by the core promoter that is driven by Sp-1 a...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Investigative Pathology
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868231/ https://ncbi.nlm.nih.gov/pubmed/12875982 |
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