FcγRI Up-Regulation Induced by Local Adenoviral-Mediated Interferon-γ Production Aggravates Chondrocyte Death during Immune Complex-Mediated Arthritis

Using various FcγR-deficient mice, we have obtained suggestive evidence that FcγRI on macrophages is responsible for severe cartilage destruction during arthritis mediated by immune complexes (ICs). This role of FcγRI is pronounced in the presence of activated Th1 cells and a likely Th1 cell-derived...

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Autores principales: Nabbe, Karin C., van Lent, Peter L., Holthuysen, Astrid E., Kolls, Jay K., Verbeek, Sjef, van den Berg, Wim B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868221/
https://ncbi.nlm.nih.gov/pubmed/12875993
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