Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1

BACKGROUND: AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear. Here we investigate whether altering relative expressi...

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Autori principali: Tsuzuki, Shinobu, Hong, Dengli, Gupta, Rajeev, Matsuo, Keitaro, Seto, Masao, Enver, Tariq
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868041/
https://ncbi.nlm.nih.gov/pubmed/17503961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040172
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