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Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1

BACKGROUND: AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear. Here we investigate whether altering relative expressi...

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Main Authors: Tsuzuki, Shinobu, Hong, Dengli, Gupta, Rajeev, Matsuo, Keitaro, Seto, Masao, Enver, Tariq
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868041/
https://ncbi.nlm.nih.gov/pubmed/17503961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040172
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