Senescence Marker Protein-30 Knockout Mouse Liver Is Highly Susceptible to Tumor Necrosis Factor-α- and Fas-Mediated Apoptosis

Senescence marker protein-30 (SMP30) is a calcium-binding protein that decreases in an androgen-independent manner with aging. To elucidate the physiological role of this protein, we introduced a null mutation of the SMP30 gene into the germ line of mice. Despite the complete lack of SMP30 (SMP30−/−...

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Main Authors: Ishigami, Akihito, Fujita, Toshiko, Handa, Setsuko, Shirasawa, Takuji, Koseki, Haruhiko, Kitamura, Tsuneo, Enomoto, Nobuyuki, Sato, Nobuhiro, Shimosawa, Tatsuo, Maruyama, Naoki
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867294/
https://ncbi.nlm.nih.gov/pubmed/12368201
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