Enteric Expression of the Integrin α(v)β(6) Is Essential for Nematode-Induced Mucosal Mast Cell Hyperplasia and Expression of the Granule Chymase, Mouse Mast Cell Protease-1

The immunoregulatory cytokine transforming growth factor (TGF)-β(1) is secreted as a biologically inactive complex with latency-associated peptide, which must be modified by local factors to expose the functionally active cytokine. The epithelial integrin α(v)β(6) mediates local activation of TGF-β(...

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Autors principals: Knight, Pamela A., Wright, Steven H., Brown, Jeremy K., Huang, Xiaozhu, Sheppard, Dean, Miller, Hugh R. P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2002
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867270/
https://ncbi.nlm.nih.gov/pubmed/12213704
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