A Short Mutational Hot Spot in the First Intron of BCL-6 Is Associated with Increased BCL-6 Expression and with Longer Overall Survival in Large B-Cell Lymphomas

BCL-6 somatic mutations have been described in normal and tumoral B lymphocytes, associated with germinal center transit. We analyzed mutations in the major mutation cluster of BCL-6 in a series of 45 large B-cell lymphomas (LBCLs) and 15 Burkitt’s lymphomas, and their relation to the level of BCL-6...

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Main Authors: Artiga, María-Jesús, Sáez, Ana-Isabel, Romero, Cristina, Sánchez-Beato, Margarita, Mateo, Mari-Sol, Navas, Concepción, Mollejo, Manuela, Piris, Miguel A.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867208/
https://ncbi.nlm.nih.gov/pubmed/11943722
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