The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies

Susceptibility to lead toxicity in MT-null mice and cells, lacking the major forms of the metallothionein (MT) gene, was compared to wild-type (WT) mice or cells. Male MT-null and WT mice received lead in the drinking water (0 to 4000 ppm) for 10 to 20 weeks. Lead did not alter body weight in any gr...

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Main Authors: Qu, Wei, Diwan, Bhalchandra A., Liu, Jie, Goyer, Robert A., Dawson, Tammy, Horton, John L., Cherian, M. George, Waalkes, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867192/
https://ncbi.nlm.nih.gov/pubmed/11891201
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