The Magnitude of Brain Lipid Peroxidation Correlates with the Extent of Degeneration but Not with Density of Neuritic Plaques or Neurofibrillary Tangles or with APOE Genotype in Alzheimer’s Disease Patients

Numerous post mortem studies have demonstrated increased accumulation of lipid peroxidation products in diseased regions of Alzheimer’s disease (AD) brain; however, few have used techniques that quantify the magnitude of lipid peroxidation in vivo. F(2)-isoprostanes (F(2)-IsoP’s) are exclusive produ...

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Hlavní autoři: Montine, Thomas J., Markesbery, William R., Zackert, William, Sanchez, Stephanie C., Roberts, L. Jackson, Morrow, Jason D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 1999
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866881/
https://ncbi.nlm.nih.gov/pubmed/10487843
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