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Genistein Inhibits Constitutive and Inducible NFκB Activation and Decreases IL-8 Production by Human Cystic Fibrosis Bronchial Gland Cells

The inflammatory pathogenesis in airways of patients with cystic fibrosis (CF) is still unresolved. We demonstrate here that in in situ human ΔF508 homozygous CF bronchial tissues, submucosal gland cells exhibit an absence of inhibitor factor κBα (IκBα) and high levels of chemokine interleukin-8 (IL...

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Autors principals: Tabary, Olivier, Escotte, Sandie, Couetil, Jean Paul, Hubert, Dominique, Dusser, Daniel, Puchelle, Edith, Jacquot, Jacky
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866865/
https://ncbi.nlm.nih.gov/pubmed/10433940
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