Genistein Inhibits Constitutive and Inducible NFκB Activation and Decreases IL-8 Production by Human Cystic Fibrosis Bronchial Gland Cells

The inflammatory pathogenesis in airways of patients with cystic fibrosis (CF) is still unresolved. We demonstrate here that in in situ human ΔF508 homozygous CF bronchial tissues, submucosal gland cells exhibit an absence of inhibitor factor κBα (IκBα) and high levels of chemokine interleukin-8 (IL...

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Main Authors: Tabary, Olivier, Escotte, Sandie, Couetil, Jean Paul, Hubert, Dominique, Dusser, Daniel, Puchelle, Edith, Jacquot, Jacky
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 1999
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866865/
https://ncbi.nlm.nih.gov/pubmed/10433940
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