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Acquisition of the Glioblastoma Phenotype during Astrocytoma Progression Is Associated with Loss of Heterozygosity on 10q25-qter

Loss of heterozygosity on chromosome 10 (LOH#10) is the most frequent genetic alteration in glioblastomas and occurs in more than 80% of cases. We recently reported that PTEN (MMAC1) on 10q23.3 is mutated in approximately 30% of primary (de novo) glioblastomas but rarely in secondary glioblastomas t...

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主要な著者: Fujisawa, Hironori, Kurrer, Michael, Reis, Rui M., Yonekawa, Yasuhiro, Kleihues, Paul, Ohgaki, Hiroko
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Investigative Pathology 1999
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866845/
https://ncbi.nlm.nih.gov/pubmed/10433932
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