Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice

K-Cl cotransport activity in rbc is a major determinant of rbc volume and density. Pathologic activation of erythroid K-Cl cotransport activity in sickle cell disease contributes to rbc dehydration and cell sickling. To address the roles of individual K-Cl cotransporter isoforms in rbc volume homeos...

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Main Authors: Rust, Marco B., Alper, Seth L., Rudhard, York, Shmukler, Boris E., Vicente, Rubén, Brugnara, Carlo, Trudel, Marie, Jentsch, Thomas J., Hübner, Christian A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866252/
https://ncbi.nlm.nih.gov/pubmed/17510708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30630
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