MDA-5 Is Cleaved in Poliovirus-Infected Cells

Infections with RNA viruses are sensed by the innate immune system through membrane-bound Toll-like receptors or the cytoplasmic RNA helicases RIG-I and MDA-5. It is believed that MDA-5 is crucial for sensing infections by picornaviruses, but there have been no studies on the role of this protein du...

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Detalhes bibliográficos
Main Authors: Barral, Paola M., Morrison, Juliet M., Drahos, Jennifer, Gupta, Pankaj, Sarkar, Devanand, Fisher, Paul B., Racaniello, Vincent R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866155/
https://ncbi.nlm.nih.gov/pubmed/17267501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01360-06
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