Á lódáil...
A Mutation in Alpha Helix 3 of CA Renders Human Immunodeficiency Virus Type 1 Cyclosporin A Resistant and Dependent: Rescue by a Second-Site Substitution in a Distal Region of CA
The replication of many isolates of human immunodeficiency virus type 1 (HIV-1) is enhanced by binding of the host cell protein cyclophilin A (CypA) to the viral capsid protein (CA). The immunosuppressive drug cyclosporine A (CsA) and its nonimmunosuppressive analogs bind with high affinity to CypA...
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Main Authors: | , |
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Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
American Society for Microbiology
2007
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1866112/ https://ncbi.nlm.nih.gov/pubmed/17267487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02634-06 |
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