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Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein

Human papillomavirus (HPV) E6 oncoprotein targets certain tumor suppressors such as MAGI-1 and SAP97/hDlg for degradation. A short peptide at the C terminus of E6 interacts specifically with the PDZ domains of these tumor suppressors, which is a property unique to high-risk HPVs that are associated...

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Detalhes bibliográficos
Main Authors: Zhang, Yi, Dasgupta, Jhimli, Ma, Runlin Z., Banks, Lawrence, Thomas, Miranda, Chen, Xiaojiang S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866053/
https://ncbi.nlm.nih.gov/pubmed/17267502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02044-06
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