Heparan Sulfate Binding Can Contribute to the Neurovirulence of Neuroadapted and Nonneuroadapted Sindbis Viruses

Cell culture-adapted laboratory strains of Sindbis virus (SB) exhibit efficient initial attachment to cell surface heparan sulfate (HS) receptors. In contrast, non-cell-adapted strains, such as the SB consensus sequence virus TR339, interact weakly with HS and cell surfaces. Regardless of their HS b...

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Detalhes bibliográficos
Main Authors: Ryman, Kate D., Gardner, Christina L., Burke, Crystal W., Meier, Kathryn C., Thompson, Joseph M., Klimstra, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866052/
https://ncbi.nlm.nih.gov/pubmed/17215278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02494-06
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