Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to That with Either Malaria Vaccine Alone

The RTS,S/AS02A protein-based vaccine consistently demonstrates significant protection against infection with Plasmodium falciparum malaria and also against clinical malaria and severe disease in children in areas of endemicity. Here we demonstrate with rhesus macaques that priming with a replicatio...

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Detalhes bibliográficos
Main Authors: Stewart, V. Ann, McGrath, Shannon M., Dubois, Patrice M., Pau, Maria G., Mettens, Pascal, Shott, Joseph, Cobb, Michelle, Burge, J. Robert, Larson, David, Ware, Lisa A., Demoitie, Marie-Ange, Weverling, Gerrit Jan, Bayat, Babak, Custers, Jerome H. H. V., Dubois, Marie-Claude, Cohen, Joe, Goudsmit, Jaap, Heppner, D. Gray
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865796/
https://ncbi.nlm.nih.gov/pubmed/17307942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01879-06
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