Safety and Immunogenicity of an Enterotoxigenic Escherichia coli Vaccine Patch Containing Heat-Labile Toxin: Use of Skin Pretreatment To Disrupt the Stratum Corneum

Transcutaneous immunization allows safe delivery of native heat-labile enterotoxin (LT) from Escherichia coli via application of a simple patch. Physical disruption of the stratum corneum can improve the efficiency of delivery. In the current study, the stratum corneum was disrupted using an electro...

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Detalhes bibliográficos
Main Authors: Glenn, Gregory M., Villar, Christina P., Flyer, David C., Bourgeois, A. Louis, McKenzie, Robin, Lavker, Robert M., Frech, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865773/
https://ncbi.nlm.nih.gov/pubmed/17261601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01740-06
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