A Defined O-Antigen Polysaccharide Mutant of Francisella tularensis Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity

Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol, and its ability to produce severe morbidity and high mortality. The identification and characterization of th...

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Detalhes bibliográficos
Main Authors: Sebastian, Shite, Dillon, Simon T., Lynch, Jillian G., Blalock, LeeAnn T., Balon, Emmy, Lee, Kristin T., Comstock, Laurie E., Conlan, J. Wayne, Rubin, Eric J., Tzianabos, Arthur O., Kasper, Dennis L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865767/
https://ncbi.nlm.nih.gov/pubmed/17296751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01789-06
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