Pet, a Non-AB Toxin, Is Transported and Translocated into Epithelial Cells by a Retrograde Trafficking Pathway

The plasmid-encoded toxin (Pet) of enteroaggregative Escherichia coli is a 104-kDa autotransporter protein that exhibits proteolytic activity against the actin-binding protein α-fodrin. Intracellular cleavage of epithelial fodrin by Pet disrupts the actin cytoskeleton, causing both cytotoxic and ent...

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Detalhes bibliográficos
Main Authors: Navarro-García, Fernando, Canizalez-Roman, Adrián, Burlingame, Kaitlin E., Teter, Ken, Vidal, Jorge E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865752/
https://ncbi.nlm.nih.gov/pubmed/17296748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01515-06
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