Inhibition of phospholipase D blocks activation of fibrinogen-adherent neutrophils by tumor necrosis factor.

Tumor necrosis factor stimulates fibrinogen-adherent neutrophils to produce a dramatic oxidative burst; the resulting superoxide and other products may contribute to tissue damage in severe infection. Inhibitors of the phospholipase D pathway blocked this activation without affecting cell adherence...

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Vydáno v:	Infect Immun
Hlavní autoři:	Frank, M O, Sullivan, G W, Carper, H T, Mandell, G L
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1994
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186555/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8188387/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.6.2622-2624.1994
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