Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes.

Mycobacterium bovis BCG was genetically engineered to express and secrete mouse interleukin-2 (IL-2) and rat IL-2. Genes encoding IL-2 were inserted into an Escherichia coli-BCG shuttle plasmid under the control of the BCG HSP60 promoter. To facilitate study of proteins produced in this system, the...

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Hauptverfasser: O'Donnell, M A, Aldovini, A, Duda, R B, Yang, H, Szilvasi, A, Young, R A, DeWolf, W C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC186538/
https://ncbi.nlm.nih.gov/pubmed/8188376
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