Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes.

Mycobacterium bovis BCG was genetically engineered to express and secrete mouse interleukin-2 (IL-2) and rat IL-2. Genes encoding IL-2 were inserted into an Escherichia coli-BCG shuttle plasmid under the control of the BCG HSP60 promoter. To facilitate study of proteins produced in this system, the...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	O'Donnell, M A, Aldovini, A, Duda, R B, Yang, H, Szilvasi, A, Young, R A, DeWolf, W C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186538/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8188376/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.6.2508-2514.1994
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