Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate.

Folate deficiency enhances colorectal carcinogenesis in dimethylhydrazine-treated rats. Folate is an important mediator of DNA methylation, an epigenetic modification of DNA that is known to be dysregulated in the early stages of colorectal cancer. This study investigated the effect of dimethylhydra...

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Hlavní autoři: Kim, Y. I., Pogribny, I. P., Salomon, R. N., Choi, S. W., Smith, D. E., James, S. J., Mason, J. B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865189/
https://ncbi.nlm.nih.gov/pubmed/8863662
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