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PTEN-mediated segregation of phosphoinositides at the apical membrane controls epithelial morphogenesis through Cdc42
Formation of the apical surface and lumen is a fundamental, yet poorly understood, step in epithelial organ development. We show that PTEN localizes to the apical plasma membrane during epithelial morphogenesis to mediate the enrichment of PtdIns(4,5)P2 at this domain during cyst development in thre...
Sparad:
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1865103/ https://ncbi.nlm.nih.gov/pubmed/17254974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.11.051 |
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