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A rapid reaction analysis of uracil DNA glycosylase indicates an active mechanism of base flipping
Uracil DNA glycosylase (UNG) is the primary enzyme for the removal of uracil from the genome of many organisms. A key question is how the enzyme is able to scan large quantities of DNA in search of aberrant uracil residues. Central to this is the mechanism by which it flips the target nucleotide out...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1865060/ https://ncbi.nlm.nih.gov/pubmed/17284454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm018 |
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