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Insights into Fanconi Anaemia from the structure of human FANCE
Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the FA core complex, monoubiquitinates the downstream FANCD2 protein. The F...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1865054/ https://ncbi.nlm.nih.gov/pubmed/17308347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm033 |
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