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Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic mice.

Treatment with a single low dose (80 to 800 ng) of interleukin-1 (IL-1) 24 h before a lethal bacterial challenge in granulocytopenic and in normal mice enhances nonspecific resistance. The mechanism behind this protection has only partially been elucidated. Since IL-1 induces production of tumor nec...

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Published in:Infect Immun
Main Authors: Vogels, M T, Hermsen, C C, Huys, H L, Eling, W M, van der Meer, J W
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186467/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8168971/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.5.2065-2070.1994
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