Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model.
Staphylococcus aureus alpha-toxin is a membrane-damaging exoprotein that oligomerizes to form transmembrane pores. Chemical modification of histidines with diethylpyrocarbonate has been shown to reduce the hemolytic activity of alpha-toxin, suggesting that one or more of the histidine residues is im...
Enregistré dans:
| Publié dans: | Infect Immun |
|---|---|
| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1994
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186423/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8168947/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.5.1843-1847.1994 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|