Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

We demonstrate the efficacy of double-stranded RNA-mediated interference (RNAi) of gene expression in generating “knock-out” phenotypes for specific proteins in several Drosophila cell lines. We prove the applicability of this technique for studying signaling cascades by dissecting the well-characte...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Clemens, James C., Worby, Carolyn A., Simonson-Leff, Nancy, Muda, Marco, Maehama, Tomohiko, Hemmings, Brian A., Dixon, Jack E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18635/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110149597
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